On July 3rd, 2025, the American Head and Neck Society (AHNS) issued a powerful statement reaffirming its support for universal HPV vaccination as a critical tool in the prevention of HPV-associated oropharyngeal cancers. Citing overwhelming scientific evidence, the AHNS highlighted the safety and efficacy of the HPV vaccine, its ability to prevent multiple cancer types, and its current underutilization, particularly among eligible boys and young men. The society called upon healthcare providers, public health authorities, and policymakers to intensify efforts to promote vaccine uptake and address barriers to access and misinformation.
However, while the long-term impact of widespread HPV vaccination is promising, the short- and medium-term epidemiological benefit—especially in reducing the incidence of HPV-positive oropharyngeal cancers in adults—may be limited. Most cases currently diagnosed occur in patients over the age of 40 who were never eligible for vaccination in adolescence. As a result, we are unlikely to see a significant decrease in incidence over the next decade, even with improved vaccination rates. This reality underscores the continued need for effective treatment strategies for HPV-related oropharyngeal cancers.
In this context, Transoral Robotic Surgery (TORS) has gained increasing support as a frontline treatment option. The latest ASCO guideline update (feb 2025) endorses TORS as a valid surgical approach for select patients with HPV-positive oropharyngeal squamous cell carcinoma, offering excellent oncologic control with the added benefit of reduced long-term toxicity compared to traditional chemoradiation. As head and neck robotic surgeons, we must continue to advocate for both preventive strategies like vaccination and technologically advanced surgical solutions like TORS to address the dual challenge of current treatment needs and future prevention.
J Granell. July 5, 2025
PD. If you are a patient you can get more information here on:
- HPV and oropharyngeal cancer (FAQ)
- Information for patients on Minimally Invasive Surgery and Robotic Surgery